![]() The DRG participates in sensory transduction and modulation, including pain transmission. A proper understanding of the significance and functioning of the DRG can help improve the diagnosis and treatment of clinical outcomes. Additionally, it is noted that DRG is an active participant in peripheral processes, including PAF injury, inflammation, and neuropathic pain development. Over the last decade, the DRG is now recognized as a viable option for neuromodulation therapy electrical stimulation of primary sensory neuron somata is also considered a viable option in treating chronic pain. The DRG has been the focus of numerous interventions, including dorsal rhizotomy or gangliectomy, dorsal root entry zone (DREZ) lesioning (an adjacent related neural target), conventional radiofrequency denervation, pulsed radiofrequency, and steroid injection. The earliest technique of anesthetic infiltration of DRG was reported in 1949. The role of DRG in chronic pain has been well established. They carry sensory messages from various receptors (i.e., pain and temperature) at the periphery towards the central nervous system for a response. Anatomically, a dorsal root ganglion (DRG) emerges from the dorsal root of the spinal nerves. Dorsal nerve roots carry sensory neural signals to the central nervous system (CNS) from the peripheral nervous system (PNS). ![]()
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